ASTRO-LAB – Assessment of the benefit/risk ratio of long-acting beta-agonists in asthma in routine care

Within this project, we investigate the long-term impact of asthma patients’ self-management behaviors on their health outcomes, as well as several modifiable factors that may influence how patients self-manage their asthma. We have conducted a cohort study in France and the United Kingdom that follows up patients (adults and children) for up to 2 years to monitor telephonically their medication use and health outcomes. Available electronic medical records and health insurance data are analyzed to provide complementary information. Patients, caregivers, and health care providers also report on their experiences, perceptions and behaviors (e.g. adherence, support with self-management from caregivers and GPs) via online surveys. We aim to examine the relationships between these key players in the care partnership, and how they impact on behaviors and health outcomes longitudinally. This investigation will result in recommendations to improve health communication in asthma, with particular focus on supporting self-management.


The ASTRO-LAB consortium includes 7 partners with a diverse range of expertise.

Eric van Ganse, Laurent Laforest, Sandrine Herbage, Maeva Nolin, Flore Jacoud, Carole Langlois (Pharmacoepidemiology Unit, Université Claude Bernard Lyon 1, Lyon, France)

Richard Hubbard Jack Gibson (University of Nottingham, UK)

Nathalie Texier, Stephane Schuck, Helene Le Cloarec, Raphael Germain, Mathilde Pouriel (Kappa Santé SAS, Paris, France)

David Ansell, Bhullar Harshvinder, Louise Pinder (IMS Health, London, UK)

Montserrat Ferrer, Gimena Hernandez, Olaz Garin, Angels Pont, Marc Marti (Consortio Mar Parc de Salut de Barcelona, IMIM< Barcelona, Spain)

Ana Valcarcel (Lyon Ingénierie Projets, Lyon, France)

Marijn de Bruin, Alexandra Dima (ASCoR, University of Amsterdam, Netherlands)

Status: ongoing from December 2011
Financiering: European Commission FP7 Programme